Mol Carcinog 52:96–102Īlbalawi IA, Mir R, Duhier FA (2020) Genetic effects of vascular endothelial growth factor A (VEGF-A) and its association with disease progression in breast cancer population of Saudi Arabia. In conclusion, the genetic variants VEGFA rs25648, VEGFR2 rs2071559, and VEGI rs6478106 revealed a significant association with increased breast cancer risk in Egyptian patients.Ībsenger G, Szkandera J, Stotz M, Pichler M, Winder T et al (2013) A common and functional gene variant in the vascular endothelial growth factor a predicts clinical outcome in early-stage breast cancer. Serum levels of VEGFA, VEGI, and HIF1A were considerably greater in women with breast cancer than in the control ( p < 0.001). ![]() There was a significant association between the VEGFA rs25648 C allele and breast cancer risk (OR 2.5, 95% CI 1.7–3.6, p 0.05). Serum levels of VEGF, VEGFR2, VEGI, and HIF1A proteins in breast cancer patients and controls were measured by ELISA. VEGFA rs25648 genotyping was performed using (ARMS) PCR technique while VEGFR2 rs2071559, VEGI rs6478106, and HIF-1α rs11549465 were genotyped by the PCR–RFLP method. The study included 154 breast cancer patients and 132 apparently healthy age-matched females as a control group. The aim of the current study was to determine whether certain polymorphisms in the genes of vascular endothelial growth factor A (VEGFA), vascular endothelial growth factor receptor 2 (VEGFR2), vascular endothelial growth inhibitor (VEGI), and hypoxia-inducible factor-1α (HIF1A) associated with breast cancer development. ![]() Polymorphisms in the angiogenesis pathway have been implicated previously in cancer risk and prognosis. Breast cancer is the most common type of cancer in Egyptian females.
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